Bacterial resistance to the tetracyclines

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Tetracyclines in veterinary medicine and bacterial resistance to them

Since their discovery in 1945, tetracyclines have been used extensively in the therapy and prophylaxis of infectious diseases and as growth promoters. These wide applications have led to the equally fast spread of tetracycline resistant strains of gram-positive and gram-negative bacterial genera, including strains belonging to pathogenic as well as nonpathogenic species. Nonpathogenic bacteria ...

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Tetracyclines in Food and Feedingstuffs: From Regulation to Analytical Methods, Bacterial Resistance, and Environmental and Health Implications

Antibiotics are widely used as growth promoters in animal husbandry; among them, the tetracyclines are a chemical group of relevance, due to their wide use in agriculture, surpassing in quantities applied almost every other antibiotic family. Seeing the considerable amounts of tetracyclines used worldwide, monitoring of these antibiotics is paramount. Advances must be made in the analysis of an...

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The tetracyclines.

The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.

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Bacterial Resistance to Hospital Disinfection

With the number of infections caused by bacteria that are multidrug resistant (MDR) increasing, it is imperative that these infections can be controlled. Biocides are used to prevent contamination in a variety of topical and hard-surface applications and are an essential component of infection control in hospitals. They are also used for disinfection and preservation of foodstuffs and within th...

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The lactococcal secondary multidrug transporter LmrP confers resistance to lincosamides, macrolides, streptogramins and tetracyclines.

The active efflux of toxic compounds by (multi)drug transporters is one of the mechanisms that bacteria have developed to resist cytotoxic drugs. The authors describe the role of the lactococcal secondary multidrug transporter LmrP in the resistance to a broad range of clinically important antibiotics. Cells expressing LmrP display an increased resistance to the lincosamide, streptogramin, tetr...

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ژورنال

عنوان ژورنال: Microbiological Reviews

سال: 1978

ISSN: 0146-0749

DOI: 10.1128/mr.42.4.707-724.1978